synthesis of 4,4'-bis-pyrimidines and some related bis-fused pyrimidines
نویسندگان
چکیده
2,2'-disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin (6), bis-purines (7), and bis-isothiazolopyrimidines (8). two bis-imidazo[l,2-a] pyrimidines (9 and 10) have also been prepared
منابع مشابه
SYNTHESIS OF 4,4'-BIS-PYRIMIDINES AND SOME RELATED BIS-FUSED PYRIMIDINES
2,2'-Disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. Some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin (6), ...
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BACKGROUND α-Bromination of the side chain of aromatic ketones using NBS in the presence of p-toluenesulfonic acid (p-TsOH) in acetonitrile is very common. However, regioselective bromination of bis and tris(ω-bromoacetophenones) with NBS in the presence of p-TsOH in acetonitrile under microwave irradiation is quite novel. The bis- and tris(ω-bromoacetophenones) are used in synthesis of bis and...
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عنوان ژورنال:
journal of sciences islamic republic of iranجلد ۶، شماره ۳، صفحات ۰-۰
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